Development of a multiphase perfusion model for biomimetic reduced-order dense tumors

Abstract Dense fibrous extracellular constitution of solid tumors exerts high resistance to diffusive transport into it; additionally, the scarcity blood and lymphatic flows hinders convection. The complexity fluidic mechanisms in such tumor environments still presents open questions with translational end goals. For example, clinical diagnosis targeted drug delivery platforms for dense can ideally benefit from a quantitative framework on plasma uptake tumor. In this study, we present computational model physical parameters that may influence percolation penetration simple biomimetic geometry. implements three-phase viscous-laminar transient simulation mimic physics inside tumor-adhering vessel measures constituent volume fractions three considered phases, viz. plasma, RBCs (red cells, also known as “erythrocytes”), WBCs (white “leukocytes”) at different flow times, while simultaneously recording pressure velocity entry point tumor’s space. Subsequently, quantify perfusion within zone, proposed reduced-order two-dimensional zone its space fenestra diameters: 0.1, 0.3, 0.5 µm; simulations were two-phase transient. findings support hypothesis is proportional leakiness modulated by size openings, rate decays diffusion distance.